Tuning PFKFB3 Bisphosphatase Activity Through Allosteric Interference

The human inducible phospho-fructokinase bisphosphatase isoform 3, PFKFB3, is a crucial regulatory node in the cellular metabolism. The enzyme is an important modulator regulating the intracellular fructose-2,6-bisphosphate level. PFKFB3 is a bifunctional enzyme with an exceptionally high kinase to...

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Detalles Bibliográficos
Autores principales: Macut, Helena, Hu, Xiao, Tarantino, Delia, Gilardoni, Ettore, Clerici, Francesca, Regazzoni, Luca, Contini, Alessandro, Pellegrino, Sara, Luisa Gelmi, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937325/
https://www.ncbi.nlm.nih.gov/pubmed/31889092
http://dx.doi.org/10.1038/s41598-019-56708-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937325/
https://www.ncbi.nlm.nih.gov/pubmed/31889092
http://dx.doi.org/10.1038/s41598-019-56708-0

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