Marburg virus pathogenesis – differences and similarities in humans and animal models

Marburg virus (MARV) is a highly pathogenic virus associated with severe disease and mortality rates as high as 90%. Outbreaks of MARV are sporadic, deadly, and often characterized by a lack of resources and facilities to diagnose and treat patients. There are currently no approved vaccines or treat...

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Autores principales: Shifflett, Kyle, Marzi, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937685/
https://www.ncbi.nlm.nih.gov/pubmed/31888676
http://dx.doi.org/10.1186/s12985-019-1272-z
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author Shifflett, Kyle
Marzi, Andrea
author_facet Shifflett, Kyle
Marzi, Andrea
author_sort Shifflett, Kyle
collection PubMed
description Marburg virus (MARV) is a highly pathogenic virus associated with severe disease and mortality rates as high as 90%. Outbreaks of MARV are sporadic, deadly, and often characterized by a lack of resources and facilities to diagnose and treat patients. There are currently no approved vaccines or treatments, and the chaotic and infrequent nature of outbreaks, among other factors, makes testing new countermeasures during outbreaks ethically and logistically challenging. Without field efficacy studies, researchers must rely on animal models of MARV infection to assess the efficacy of vaccines and treatments, with the limitations being the accuracy of the animal model in recapitulating human pathogenesis. This review will compare various animal models to the available descriptions of human pathogenesis and aims to evaluate their effectiveness in modeling important aspects of Marburg virus disease.
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spelling pubmed-69376852019-12-31 Marburg virus pathogenesis – differences and similarities in humans and animal models Shifflett, Kyle Marzi, Andrea Virol J Review Marburg virus (MARV) is a highly pathogenic virus associated with severe disease and mortality rates as high as 90%. Outbreaks of MARV are sporadic, deadly, and often characterized by a lack of resources and facilities to diagnose and treat patients. There are currently no approved vaccines or treatments, and the chaotic and infrequent nature of outbreaks, among other factors, makes testing new countermeasures during outbreaks ethically and logistically challenging. Without field efficacy studies, researchers must rely on animal models of MARV infection to assess the efficacy of vaccines and treatments, with the limitations being the accuracy of the animal model in recapitulating human pathogenesis. This review will compare various animal models to the available descriptions of human pathogenesis and aims to evaluate their effectiveness in modeling important aspects of Marburg virus disease. BioMed Central 2019-12-30 /pmc/articles/PMC6937685/ /pubmed/31888676 http://dx.doi.org/10.1186/s12985-019-1272-z Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Shifflett, Kyle
Marzi, Andrea
Marburg virus pathogenesis – differences and similarities in humans and animal models
title Marburg virus pathogenesis – differences and similarities in humans and animal models
title_full Marburg virus pathogenesis – differences and similarities in humans and animal models
title_fullStr Marburg virus pathogenesis – differences and similarities in humans and animal models
title_full_unstemmed Marburg virus pathogenesis – differences and similarities in humans and animal models
title_short Marburg virus pathogenesis – differences and similarities in humans and animal models
title_sort marburg virus pathogenesis – differences and similarities in humans and animal models
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937685/
https://www.ncbi.nlm.nih.gov/pubmed/31888676
http://dx.doi.org/10.1186/s12985-019-1272-z
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