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Distinct epigenetic features of tumor-reactive CD8+ T cells in colorectal cancer patients revealed by genome-wide DNA methylation analysis

BACKGROUND: Tumor-reactive CD8+ tumor-infiltrating lymphocytes (TILs) represent a subtype of T cells that can recognize and destroy tumor specifically. Understanding the regulatory mechanism of tumor-reactive CD8+ T cells has important therapeutic implications. Yet the DNA methylation status of this...

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Detalles Bibliográficos
Autores principales:	Yang, Rui, Cheng, Sijin, Luo, Nan, Gao, Ranran, Yu, Kezhuo, Kang, Boxi, Wang, Li, Zhang, Qiming, Fang, Qiao, Zhang, Lei, Li, Chen, He, Aibin, Hu, Xueda, Peng, Jirun, Ren, Xianwen, Zhang, Zemin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937914/ https://www.ncbi.nlm.nih.gov/pubmed/31892342 http://dx.doi.org/10.1186/s13059-019-1921-y

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