Development and Evaluation of in-situ Nasal Gel Formulations of Nanosized Transferosomal Sumatriptan: Design, Optimization, in vitro and in vivo Evaluation

BACKGROUND: Sumatriptan succinate (SUT) is a potent drug used for relieving or ending migraine and cluster headaches. SUT bioavailability is low (15%) when it is taken orally owing to its gastric breakdown and bloodstream before reaching the target arteries. AIM: The aim of the study was to enhance...

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Detalles Bibliográficos
Autores principales: Omar, Mahmoud M, Eleraky, Nermin E, El Sisi, Amani M, Ali Hasan, Omiya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938197/
https://www.ncbi.nlm.nih.gov/pubmed/31920290
http://dx.doi.org/10.2147/DDDT.S235004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938197/
https://www.ncbi.nlm.nih.gov/pubmed/31920290
http://dx.doi.org/10.2147/DDDT.S235004

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