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Nopp140-mediated concentration of telomerase in Cajal bodies regulates telomere length

Cajal bodies (CBs) are nuclear organelles concentrating two kinds of RNA–­protein complexes (RNPs), spliceosomal small nuclear (sn), and small CB-specific (sca)RNPs. Whereas the CB marker protein coilin is responsible for retaining snRNPs, the tether for scaRNPs is not known. Here we show that Nopp1...

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Detalles Bibliográficos
Autores principales: Bizarro, Jonathan, Bhardwaj, Amit, Smith, Susan, Meier, U. Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938241/
https://www.ncbi.nlm.nih.gov/pubmed/31664887
http://dx.doi.org/10.1091/mbc.E19-08-0429