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Modification of an aggressive model of Alport Syndrome reveals early differences in disease pathogenesis due to genetic background
The link between mutations in collagen genes and the development of Alport Syndrome has been clearly established and a number of animal models, including knock-out mouse lines, have been developed that mirror disease observed in patients. However, it is clear from both patients and animal models tha...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938516/ https://www.ncbi.nlm.nih.gov/pubmed/31892712 http://dx.doi.org/10.1038/s41598-019-56837-6 |