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Notch3 Promotes Prostate Cancer-Induced Bone Lesion Development via MMP-3

Prostate cancer metastases primarily localize in the bone where they induce a unique osteoblastic response. Elevated Notch activity is associated with high-grade disease and metastasis. To address how Notch affects prostate cancer bone lesions, we manipulated Notch expression in mouse tibia xenograf...

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Detalles Bibliográficos
Autores principales: Ganguly, Sourik S., Hostetter, Galen, Tang, Lin, Frank, Sander B., Saboda, Kathylynn, Mehra, Rohit, Wang, Lisha, Li, Xiaohong, Keller, Evan T., Miranti, Cindy K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938550/
https://www.ncbi.nlm.nih.gov/pubmed/31467432
http://dx.doi.org/10.1038/s41388-019-0977-1