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Notch3 Promotes Prostate Cancer-Induced Bone Lesion Development via MMP-3
Prostate cancer metastases primarily localize in the bone where they induce a unique osteoblastic response. Elevated Notch activity is associated with high-grade disease and metastasis. To address how Notch affects prostate cancer bone lesions, we manipulated Notch expression in mouse tibia xenograf...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938550/ https://www.ncbi.nlm.nih.gov/pubmed/31467432 http://dx.doi.org/10.1038/s41388-019-0977-1 |