Exome sequencing reveals a high prevalence of BRCA1 and BRCA2 founder variants in a diverse population-based biobank

BACKGROUND: Pathogenic variants in BRCA1 and BRCA2 (BRCA1/2) lead to increased risk of breast, ovarian, and other cancers, but most variant-positive individuals in the general population are unaware of their risk, and little is known about prevalence in non-European populations. We investigated BRCA...

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Detalles Bibliográficos
Autores principales: Abul-Husn, Noura S., Soper, Emily R., Odgis, Jacqueline A., Cullina, Sinead, Bobo, Dean, Moscati, Arden, Rodriguez, Jessica E., Loos, Ruth J. F., Cho, Judy H., Belbin, Gillian M., Suckiel, Sabrina A., Kenny, Eimear E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938627/
https://www.ncbi.nlm.nih.gov/pubmed/31892343
http://dx.doi.org/10.1186/s13073-019-0691-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938627/
https://www.ncbi.nlm.nih.gov/pubmed/31892343
http://dx.doi.org/10.1186/s13073-019-0691-1

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