Disorders of FZ-CRD; insights towards FZ-CRD folding and therapeutic landscape

The ER is hub for protein folding. Proteins that harbor a Frizzled cysteine-rich domain (FZ-CRD) possess 10 conserved cysteine motifs held by a unique disulfide bridge pattern which attains a correct fold in the ER. Little is known about implications of disease-causing missense mutations within FZ-C...

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Detalles Bibliográficos
Autores principales: Milhem, Reham M., Ali, Bassam R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938638/
https://www.ncbi.nlm.nih.gov/pubmed/31892318
http://dx.doi.org/10.1186/s10020-019-0129-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938638/
https://www.ncbi.nlm.nih.gov/pubmed/31892318
http://dx.doi.org/10.1186/s10020-019-0129-7

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