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Disorders of FZ-CRD; insights towards FZ-CRD folding and therapeutic landscape
The ER is hub for protein folding. Proteins that harbor a Frizzled cysteine-rich domain (FZ-CRD) possess 10 conserved cysteine motifs held by a unique disulfide bridge pattern which attains a correct fold in the ER. Little is known about implications of disease-causing missense mutations within FZ-C...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938638/ https://www.ncbi.nlm.nih.gov/pubmed/31892318 http://dx.doi.org/10.1186/s10020-019-0129-7 |