Fork pausing complex engages topoisomerases at the replisome

Replication forks temporarily or terminally pause at hundreds of hard-to-replicate regions around the genome. A conserved pair of budding yeast replisome components Tof1–Csm3 (fission yeast Swi1–Swi3 and human TIMELESS–TIPIN) act as a “molecular brake” and promote fork slowdown at proteinaceous repl...

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Detalles Bibliográficos
Autores principales: Shyian, Maksym, Albert, Benjamin, Zupan, Andreja Moset, Ivanitsa, Vitalii, Charbonnet, Gabriel, Dilg, Daniel, Shore, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938670/
https://www.ncbi.nlm.nih.gov/pubmed/31805522
http://dx.doi.org/10.1101/gad.331868.119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938670/
https://www.ncbi.nlm.nih.gov/pubmed/31805522
http://dx.doi.org/10.1101/gad.331868.119

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