Collaboration Between RSK-EphA2 and Gas6-Axl RTK Signaling in Arginine Starvation Response That Confers Resistance to EGFR Inhibitors

Many human malignancies require extracellular arginine (Arg) for survival because the key enzyme for de novo Arg biosynthesis, argininosuccinate synthetase 1 (ASS1), is silenced. Recombinant arginine deiminase (ADI-PEG20), which digests extracellular Arg, has been in clinical trials for treating ASS...

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Detalles Bibliográficos
Autores principales: Kuo, Macus Tien, Long, Yan, Tsai, Wen-Bin, Li, Ying-Ying, Chen, Helen H.W., Feun, Lynn G., Savaraj, Niramol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2019
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938815/
https://www.ncbi.nlm.nih.gov/pubmed/31887630
http://dx.doi.org/10.1016/j.tranon.2019.12.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938815/
https://www.ncbi.nlm.nih.gov/pubmed/31887630
http://dx.doi.org/10.1016/j.tranon.2019.12.003

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