Cargando…

RNA toxicity in non‐coding repeat expansion disorders

Several neurodegenerative disorders like amyotrophic lateral sclerosis (ALS) and spinocerebellar ataxia (SCA) are caused by non‐coding nucleotide repeat expansions. Different pathogenic mechanisms may underlie these non‐coding repeat expansion disorders. While gain‐of‐function mechanisms, such as to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Swinnen, Bart, Robberecht, Wim, Van Den Bosch, Ludo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939197/ https://www.ncbi.nlm.nih.gov/pubmed/31721251 http://dx.doi.org/10.15252/embj.2018101112

Ejemplares similares

Modelling amyotrophic lateral sclerosis: progress and possibilities
por: Van Damme, Philip, et al.
Publicado: (2017)

C9orf72 loss-of-function: a trivial, stand-alone or additive mechanism in C9 ALS/FTD?
por: Braems, Elke, et al.
Publicado: (2020)

Whole-genome sequencing reveals a coding non-pathogenic variant tagging a non-coding pathogenic hexanucleotide repeat expansion in C9orf72 as cause of amyotrophic lateral sclerosis
por: Herdewyn, Sarah, et al.
Publicado: (2012)

In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration
por: Pollari, Eveliina, et al.
Publicado: (2018)

Familial Adult Myoclonus Epilepsy: A Non-Coding Repeat Expansion Disorder of Cerebellar–Thalamic–Cortical Loop
por: Cuccurullo, Claudia, et al.
Publicado: (2023)

Prevention of intestinal obstruction reveals progressive neurodegeneration in mutant TDP-43 (A315T) mice
por: Herdewyn, Sarah, et al.
Publicado: (2014)

Development of Improved HDAC6 Inhibitors as Pharmacological Therapy for Axonal Charcot–Marie–Tooth Disease
por: Benoy, Veronick, et al.
Publicado: (2016)

The long non-coding RNA NEAT1 is elevated in polyglutamine repeat expansion diseases and protects from disease gene-dependent toxicities
por: Cheng, Congsheng, et al.
Publicado: (2018)

Conditional deletion of Id2 or Notch1 in oligodendrocyte progenitor cells does not ameliorate disease outcome in SOD1(G93A) mice
por: Eykens, Caroline, et al.
Publicado: (2018)

G-Quadruplexes in Repeat Expansion Disorders
por: Teng, Ye, et al.
Publicado: (2023)

Mechanisms of RNA-induced toxicity in CAG repeat disorders
por: Nalavade, R, et al.
Publicado: (2013)

RNA Phase Transitions in Repeat Expansion Disorders
por: Jain, Ankur, et al.
Publicado: (2017)

Progranulin is Neurotrophic In Vivo and Protects against a Mutant TDP-43 Induced Axonopathy
por: Laird, Angela S., et al.
Publicado: (2010)

FUS-induced neurotoxicity in Drosophila is prevented by downregulating nucleocytoplasmic transport proteins
por: Steyaert, Jolien, et al.
Publicado: (2018)

Intrinsic Disorder in Proteins with Pathogenic Repeat Expansions
por: Darling, April L., et al.
Publicado: (2017)

RNA Helicases in Microsatellite Repeat Expansion Disorders and Neurodegeneration
por: Castelli, Lydia M., et al.
Publicado: (2022)

Small non-coding RNAs add complexity to the RNA pathogenic mechanisms in trinucleotide repeat expansion diseases
por: Martí, Eulàlia, et al.
Publicado: (2013)

Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo
por: Beel, Sander, et al.
Publicado: (2017)

Progranulin reduces insoluble TDP-43 levels, slows down axonal degeneration and prolongs survival in mutant TDP-43 mice
por: Beel, Sander, et al.
Publicado: (2018)

HNRNPK alleviates RNA toxicity by counteracting DNA damage in C9orf72 ALS
por: Braems, Elke, et al.
Publicado: (2022)

Mechanisms of repeat-associated non-AUG translation in neurological microsatellite expansion disorders
por: Castelli, Lydia M., et al.
Publicado: (2021)

Beta-2 microglobulin is important for disease progression in a murine model for amyotrophic lateral sclerosis
por: Staats, Kim A., et al.
Publicado: (2013)

Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity
por: Bogaert, Elke, et al.
Publicado: (2018)

RNA biology of disease-associated microsatellite repeat expansions
por: Rohilla, Kushal J., et al.
Publicado: (2017)

Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival
por: Van Damme, Philip, et al.
Publicado: (2008)

Elongator subunit 3 (ELP3) modifies ALS through tRNA modification
por: Bento-Abreu, Andre, et al.
Publicado: (2018)

Aurintricarboxylic Acid Decreases RNA Toxicity in a C. elegans Model of Repeat Expansions
por: Braun, Maya, et al.
Publicado: (2021)

Rapamycin increases survival in ALS mice lacking mature lymphocytes
por: Staats, Kim A, et al.
Publicado: (2013)

ATXN1 repeat expansions confer risk for amyotrophic lateral sclerosis and contribute to TDP-43 mislocalization
por: Tazelaar, Gijs H P, et al.
Publicado: (2020)

Reducing EphA4 before disease onset does not affect survival in a mouse model of Amyotrophic Lateral Sclerosis
por: Rué, Laura, et al.
Publicado: (2019)

Repeat Length and RNA Expression Level Are Not Primary Determinants in CUG Expansion Toxicity in Drosophila Models
por: Le Mée, Gwenn, et al.
Publicado: (2008)

Modifiers of C9orf72 DPR toxicity implicate nucleocytoplasmic transport impairments in c9FTD/ALS
por: Jovičić, Ana, et al.
Publicado: (2015)

The Role of Nucleocytoplasmic Transport Defects in Amyotrophic Lateral Sclerosis
por: Vanneste, Joni, et al.
Publicado: (2021)

Short Tandem Repeat Expansions and RNA-Mediated Pathogenesis in Myotonic Dystrophy
por: Sznajder, Łukasz J., et al.
Publicado: (2019)

Local Tandem Repeat Expansion in Xist RNA as a Model for the Functionalisation of ncRNA
por: Brockdorff, Neil
Publicado: (2018)

Mitochondrial Dysfunction in Repeat Expansion Diseases
por: Giménez-Bejarano, Alberto, et al.
Publicado: (2023)

 Genetic Code Expansion and Optoproteomics
por: Chen, Yuting, et al.
Publicado: (2017)

Repeat RNA expansion disorders of the nervous system: post-transcriptional mechanisms and therapeutic strategies
por: Schwartz, Joshua L., et al.
Publicado: (2020)

Lowering EphA4 Does Not Ameliorate Disease in a Mouse Model for Severe Spinal Muscular Atrophy
por: Poppe, Lindsay, et al.
Publicado: (2019)

Transgenic Models of Spinocerebellar Ataxia Type 10: Modeling a Repeat Expansion Disorder
por: McFarland, Karen N., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_o9hdoiemgeghsh8aklo7v9glds