Distinct IL‐1α‐responsive enhancers promote acute and coordinated changes in chromatin topology in a hierarchical manner

How cytokine‐driven changes in chromatin topology are converted into gene regulatory circuits during inflammation still remains unclear. Here, we show that interleukin (IL)‐1α induces acute and widespread changes in chromatin accessibility via the TAK1 kinase and NF‐κB at regions that are highly enr...

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Detalles Bibliográficos
Autores principales: Weiterer, Sinah‐Sophia, Meier‐Soelch, Johanna, Georgomanolis, Theodore, Mizi, Athanasia, Beyerlein, Anna, Weiser, Hendrik, Brant, Lilija, Mayr‐Buro, Christin, Jurida, Liane, Beuerlein, Knut, Müller, Helmut, Weber, Axel, Tenekeci, Ulas, Dittrich‐Breiholz, Oliver, Bartkuhn, Marek, Nist, Andrea, Stiewe, Thorsten, van IJcken, Wilfred FJ, Riedlinger, Tabea, Schmitz, M Lienhard, Papantonis, Argyris, Kracht, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939198/
https://www.ncbi.nlm.nih.gov/pubmed/31701553
http://dx.doi.org/10.15252/embj.2019101533

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939198/
https://www.ncbi.nlm.nih.gov/pubmed/31701553
http://dx.doi.org/10.15252/embj.2019101533

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