Breaking the selectivity-uptake trade-off of photoimmunoconjugates with nanoliposomal irinotecan for synergistic multi-tier cancer targeting

BACKGROUND: Photoimmunotherapy involves targeted delivery of photosensitizers via an antibody conjugate (i.e., photoimmunoconjugate, PIC) followed by light activation for selective tumor killing. The trade-off between PIC selectivity and PIC uptake is a major drawback limiting the efficacy of photoi...

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Detalles Bibliográficos
Autores principales: Liang, Barry J., Pigula, Michael, Baglo, Yan, Najafali, Daniel, Hasan, Tayyaba, Huang, Huang-Chiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939330/
https://www.ncbi.nlm.nih.gov/pubmed/31898555
http://dx.doi.org/10.1186/s12951-019-0560-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939330/
https://www.ncbi.nlm.nih.gov/pubmed/31898555
http://dx.doi.org/10.1186/s12951-019-0560-5

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