Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer

Efforts to target glutamine metabolism for cancer therapy have focused on the glutaminase isozyme GLS. The importance of the other isozyme, GLS2, in cancer has remained unclear, and it has been described as a tumor suppressor in some contexts. Here, we report that GLS2 is upregulated and essential i...

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Detalles Bibliográficos
Autores principales: Lukey, Michael J., Cluntun, Ahmad A., Katt, William P., Lin, Miao-chong J., Druso, Joseph E., Ramachandran, Sekar, Erickson, Jon W., Le, Henry H., Wang, Zhihan-Emily, Blank, Bryant, Greene, Kai Su, Cerione, Richard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939472/
https://www.ncbi.nlm.nih.gov/pubmed/31577957
http://dx.doi.org/10.1016/j.celrep.2019.08.076

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939472/
https://www.ncbi.nlm.nih.gov/pubmed/31577957
http://dx.doi.org/10.1016/j.celrep.2019.08.076

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