Homoharringtonine exhibits potent anti-tumor effect and modulates DNA epigenome in acute myeloid leukemia by targeting SP1/TET1/5hmC

Homoharringtonine, a plant alkaloid, has been reported to suppress protein synthesis and has been approved by the US Food and Drug Administration for the treatment of chronic myeloid leukemia. Here we show that in acute myeloid leukemia (AML), homoharringtonine potently inhibits cell growth/viabilit...

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Detalles Bibliográficos
Autores principales: Li, Chenying, Dong, Lei, Su, Rui, Bi, Ying, Qing, Ying, Deng, Xiaolan, Zhou, Yile, Hu, Chao, Yu, Mengxia, Huang, Hao, Jiang, Xi, Li, Xia, He, Xiao, Zou, Dongling, Shen, Chao, Han, Li, Sun, Miao, Skibbe, Jennifer, Ferchen, Kyle, Qin, Xi, Weng, Hengyou, Huang, Huilin, Song, Chunxiao, Chen, Jianjun, Jin, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939512/
https://www.ncbi.nlm.nih.gov/pubmed/30975912
http://dx.doi.org/10.3324/haematol.2018.208835

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939512/
https://www.ncbi.nlm.nih.gov/pubmed/30975912
http://dx.doi.org/10.3324/haematol.2018.208835

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