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Responsiveness of chronic lymphocytic leukemia cells to B-cell receptor stimulation is associated with low expression of regulatory molecules of the nuclear factor-κB pathway

Chronic lymphocytic leukemia (CLL) is a disease with heterogeneous clinical and biological characteristics. Differences in Ca(2+) levels among cases, both basal and upon B-cell receptor (BCR) stimulation, may reflect heterogeneity in the pathogenesis due to cell-intrinsic factors. Our aim was to elu...

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Detalles Bibliográficos
Autores principales: Meijers, Ruud W.J., Muggen, Alice F., Leon, Leticia G., de Bie, Maaike, van Dongen, Jacques J.M., Hendriks, Rudi W., Langerak, Anton W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939541/
https://www.ncbi.nlm.nih.gov/pubmed/31097630
http://dx.doi.org/10.3324/haematol.2018.215566