Cargando…
Responsiveness of chronic lymphocytic leukemia cells to B-cell receptor stimulation is associated with low expression of regulatory molecules of the nuclear factor-κB pathway
Chronic lymphocytic leukemia (CLL) is a disease with heterogeneous clinical and biological characteristics. Differences in Ca(2+) levels among cases, both basal and upon B-cell receptor (BCR) stimulation, may reflect heterogeneity in the pathogenesis due to cell-intrinsic factors. Our aim was to elu...
Autores principales: | Meijers, Ruud W.J., Muggen, Alice F., Leon, Leticia G., de Bie, Maaike, van Dongen, Jacques J.M., Hendriks, Rudi W., Langerak, Anton W. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ferrata Storti Foundation
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939541/ https://www.ncbi.nlm.nih.gov/pubmed/31097630 http://dx.doi.org/10.3324/haematol.2018.215566 |
Ejemplares similares
-
Consistent B Cell Receptor Immunoglobulin Features Between Siblings in Familial Chronic Lymphocytic Leukemia
por: Kolijn, P. Martijn, et al.
Publicado: (2021) -
Identification of Distinct Unmutated Chronic Lymphocytic Leukemia Subsets in Mice Based on Their T Cell Dependency
por: Pal Singh, Simar, et al.
Publicado: (2018) -
The presence of CLL-associated stereotypic B cell receptors in the normal BCR repertoire from healthy individuals increases with age
por: Muggen, Alice F., et al.
Publicado: (2019) -
Cell lines generated from a chronic lymphocytic leukemia mouse model exhibit constitutive Btk and Akt signaling
por: Singh, Simar Pal, et al.
Publicado: (2017) -
Functional loss of IκBε leads to NF-κB deregulation in aggressive chronic lymphocytic leukemia
por: Mansouri, Larry, et al.
Publicado: (2015)