Transforming Growth Factor β Receptor Type I Inhibitor, Galunisertib, Has No Beneficial Effects on Aneurysmal Pathological Changes in Marfan Mice

Marfan syndrome (MFS), a connective tissue disorder caused by mutations in the fibrillin-1 (Fbn1) gene, has vascular manifestations including aortic aneurysm, dissection, and rupture. Its vascular pathogenesis is assumed to be attributed to increased transforming growth factor β (TGFβ) signaling and...

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Detalles Bibliográficos
Autores principales: Park, Jeong-Ho, Kim, Min-Seob, Ham, Seokran, Park, Eon Sub, Kim, Koung Li, Suh, Wonhee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Applied Pharmacology 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939689/
https://www.ncbi.nlm.nih.gov/pubmed/31284709
http://dx.doi.org/10.4062/biomolther.2019.042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939689/
https://www.ncbi.nlm.nih.gov/pubmed/31284709
http://dx.doi.org/10.4062/biomolther.2019.042

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