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Phospholipid prodrug conjugates of insoluble chemotherapeutic agents for ultrasound targeted drug delivery

The hydrophobicity and high potency of many therapeutic agents makes them difficult to use effectively in clinical practice. This work focuses on conjugating phospholipid tails (2T) onto podophyllotoxin (P) and its analogue (N) using a linker and characterizing the effects of their incorporation int...

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Detalles Bibliográficos
Autores principales: Márquez, Mendi G., Dotson, Rachel, Pias, Sally, Frolova, Liliya V., Tartis, Michaelann S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940203/
https://www.ncbi.nlm.nih.gov/pubmed/31911893
http://dx.doi.org/10.7150/ntno.37738