Tissue-infiltrating macrophages mediate an exosome-based metabolic reprogramming upon DNA damage

DNA damage and metabolic disorders are intimately linked with premature disease onset but the underlying mechanisms remain poorly understood. Here, we show that persistent DNA damage accumulation in tissue-infiltrating macrophages carrying an ERCC1-XPF DNA repair defect (Er1(F/−)) triggers Golgi dis...

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Detalles Bibliográficos
Autores principales: Goulielmaki, Evi, Ioannidou, Anna, Tsekrekou, Maria, Stratigi, Kalliopi, Poutakidou, Ioanna K., Gkirtzimanaki, Katerina, Aivaliotis, Michalis, Evangelou, Konstantinos, Topalis, Pantelis, Altmüller, Janine, Gorgoulis, Vassilis G., Chatzinikolaou, Georgia, Garinis, George A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940362/
https://www.ncbi.nlm.nih.gov/pubmed/31896748
http://dx.doi.org/10.1038/s41467-019-13894-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940362/
https://www.ncbi.nlm.nih.gov/pubmed/31896748
http://dx.doi.org/10.1038/s41467-019-13894-9

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