Molecular dynamics simulations of copper binding to amyloid-β Glu22 mutants

We report microsecond timescale ligand field molecular dynamics simulations of the copper complexes of three known mutants of the amyloid-β peptide, E22G, E22Q and E22K, alongside the naturally occurring sequence. We find that all three mutants lead to formation of less compact structures than the w...

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Detalles Bibliográficos
Autores principales: Mutter, Shaun T., Turner, Matthew, Deeth, Robert J., Platts, James A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940626/
https://www.ncbi.nlm.nih.gov/pubmed/31909253
http://dx.doi.org/10.1016/j.heliyon.2019.e03071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940626/
https://www.ncbi.nlm.nih.gov/pubmed/31909253
http://dx.doi.org/10.1016/j.heliyon.2019.e03071

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