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Molecular dynamics simulations of copper binding to amyloid-β Glu22 mutants
We report microsecond timescale ligand field molecular dynamics simulations of the copper complexes of three known mutants of the amyloid-β peptide, E22G, E22Q and E22K, alongside the naturally occurring sequence. We find that all three mutants lead to formation of less compact structures than the w...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940626/ https://www.ncbi.nlm.nih.gov/pubmed/31909253 http://dx.doi.org/10.1016/j.heliyon.2019.e03071 |