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Liquid chromatography method to assay tretinoin in skin layers: validation and application in skin penetration/retention studies

A liquid chromatography (LC) method for the quantification of tretinoin (TTN) in different matrices (adhesive tape, cotton and porcine skin layers, stratum corneum, viable epidermis, and dermis) was validated and applied in in vitro porcine skin penetration/retention studies. This study proposes, fo...

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Detalles Bibliográficos
Autores principales: de Oliveira, Dileusa, de Andrade, Diego Fontana, de Oliveira, Edilene Gadelha, Beck, Ruy Carlos Ruver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940676/
https://www.ncbi.nlm.nih.gov/pubmed/31909266
http://dx.doi.org/10.1016/j.heliyon.2019.e03098