Alteration of GABAergic Input Precedes Neurodegeneration of Cerebellar Purkinje Cells of NPC1-Deficient Mice

Niemann-Pick Disease Type C1 (NPC1) is a rare hereditary neurodegenerative disease belonging to the family of lysosomal storage disorders. NPC1-patients suffer from, amongst other symptoms, ataxia, based on the dysfunction and loss of cerebellar Purkinje cells. Alterations in synaptic transmission a...

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Detalles Bibliográficos
Autores principales: Rabenstein, Michael, Murr, Nico, Hermann, Andreas, Rolfs, Arndt, Frech, Moritz J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940741/
https://www.ncbi.nlm.nih.gov/pubmed/31847086
http://dx.doi.org/10.3390/ijms20246288

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940741/
https://www.ncbi.nlm.nih.gov/pubmed/31847086
http://dx.doi.org/10.3390/ijms20246288

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