Structural Requirements of N-alpha-Mercaptoacetyl Dipeptide (NAMdP) Inhibitors of Pseudomonas Aeruginosa Virulence Factor LasB: 3D-QSAR, Molecular Docking, and Interaction Fingerprint Studies

The zinc metallopeptidase Pseudomonas elastase (LasB) is a virulence factor of Pseudomonas aeruginosa (P. aeruginosa), a pathogenic bacterium that can cause nosocomial infections. The present study relates the structural analysis of 118 N-alpha-mercaptoacetyl dipeptides (NAMdPs) as LasB inhibitors....

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Detalles Bibliográficos
Autores principales: Velázquez-Libera, José Luis, Murillo-López, Juliana Andrea, F. de la Torre, Alexander, Caballero, Julio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940830/
https://www.ncbi.nlm.nih.gov/pubmed/31817391
http://dx.doi.org/10.3390/ijms20246133

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940830/
https://www.ncbi.nlm.nih.gov/pubmed/31817391
http://dx.doi.org/10.3390/ijms20246133

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