Increased Consumption of Sulfur Amino Acids by Both Sows and Piglets Enhances the Ability of the Progeny to Adverse Effects Induced by Lipopolysaccharide

SIMPLE SUMMARY: Our results suggest that maternal consumption of total sulfur amino acids exceeding the NRC 2012 recommendations by 25% during late gestation and lactation benefits sow productivity and piglet neonatal performance. Moreover, increased consumption of sulfur amino acids by both sows and post-weaned piglets improved their ability to counteract the adverse effects by lipopolysaccharide (LPS) exposure. In addition, OH-Met showed a better response than DL-Met in both neonatal and weaned piglets. Taken together, our findings indicate that it might be necessary to update the recommendations for sulfur amino acids for gestating and lactating sows. Attention should also be given to sulfur amino acids supply during an inflammatory challenge as often encountered by piglets early in life. ABSTRACT: This study determined the effects of increased consumption of sulfur amino acids (SAA), as either DL-Met or Hydroxy-Met (OH-Met), by sows and piglets on their performance and the ability of the progeny to resist a lipopolysaccharide (LPS) challenge. Thirty primiparous sows were fed a diet adequate in SAA (CON) or CON + 25% SAA, either as DL-Met or OH-Met from gestation day 85 to postnatal day 21. At 35 d old, 20 male piglets from each treatment were selected and divided into 2 groups (n = 10/treatment) for a 3 × 2 factorial design [diets (CON, DL-Met or OH-Met) and challenge (saline or LPS)]. OH-Met and/or DL-Met supplementation increased (p ≤ 0.05) piglets’ body weight gain during day 0–7 and day 7–14. Sow’s milk quality was improved in the supplemented treatments compared to the CON. The LPS challenge decreased (p ≤ 0.05) piglets’ performance from 35 to 63 d and increased (p ≤ 0.05) the levels of aspartate aminotransferase, total bilirubin, IL-1β, IL-6, TNF-a, and malondialdehyde. Plasma albumin, total protein, total antioxidant capacity and glutathione peroxidase decreased post-challenge. The results were better with OH-Met than DL-Met. The increase of Met consumption, particularly as OH-Met increased piglets’ growth performance during the lactation phase and the challenging period.