Vortioxetine Subchronically Activates Serotonergic Transmission via Desensitization of Serotonin 5-HT(1A) Receptor with 5-HT(3) Receptor Inhibition in Rats

Vortioxetine is a novel, multimodal antidepressant with unique targets, including the inhibition of the serotonin transporter (SET), of serotonin 5-HT(3) (5-HT3R), and of 5-HT(7) (5-HT7R) receptors and partial agonism to serotonin 5-HT(1A) (5-HT1AR) receptors in humans. Vortioxetine has a lower affi...

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Detalles Bibliográficos
Autores principales: Okada, Motohiro, Okubo, Ruri, Fukuyama, Kouji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940928/
https://www.ncbi.nlm.nih.gov/pubmed/31835640
http://dx.doi.org/10.3390/ijms20246235

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940928/
https://www.ncbi.nlm.nih.gov/pubmed/31835640
http://dx.doi.org/10.3390/ijms20246235

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