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Vortioxetine Subchronically Activates Serotonergic Transmission via Desensitization of Serotonin 5-HT(1A) Receptor with 5-HT(3) Receptor Inhibition in Rats
Vortioxetine is a novel, multimodal antidepressant with unique targets, including the inhibition of the serotonin transporter (SET), of serotonin 5-HT(3) (5-HT3R), and of 5-HT(7) (5-HT7R) receptors and partial agonism to serotonin 5-HT(1A) (5-HT1AR) receptors in humans. Vortioxetine has a lower affi...
Autores principales: | Okada, Motohiro, Okubo, Ruri, Fukuyama, Kouji |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940928/ https://www.ncbi.nlm.nih.gov/pubmed/31835640 http://dx.doi.org/10.3390/ijms20246235 |
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