Cargando…

Aldh2 Attenuates Stem Cell Factor/Kit-Dependent Signaling and Activation in Mast Cells

Mitochondrial aldehyde dehydrogenase (ALDH2) metabolizes endogenous and exogenous aldehydes and protects cells against oxidative injury. Inactivating genetic polymorphisms in humans are common and associate with alcohol flush reactions. However, whether mast cell Aldh2 activity impacts normal mast c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Do-Kyun, Cho, Young-Eun, Song, Byoung-Joon, Kawamoto, Toshihiro, Metcalfe, Dean D., Olivera, Ana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940998/ https://www.ncbi.nlm.nih.gov/pubmed/31835486 http://dx.doi.org/10.3390/ijms20246216

Ejemplares similares

Oncogenic D816V-KIT signaling in mast cells causes persistent IL-6 production
por: Tobío, Araceli, et al.
Publicado: (2020)

Targeting Sphingosine Kinase Isoforms Effectively Reduces Growth and Survival of Neoplastic Mast Cells With D816V-KIT
por: Bandara, Geethani, et al.
Publicado: (2018)

Selective immunocapture reveals neoplastic human mast cells secrete distinct microvesicle‐ and exosome‐like populations of KIT‐containing extracellular vesicles
por: Pfeiffer, Annika, et al.
Publicado: (2022)

Epigenetic histone modification by butyrate downregulates KIT and attenuates mast cell function
por: Gudneppanavar, Ravindra, et al.
Publicado: (2023)

Targeting the KIT Activating Switch Control Pocket: A Novel Mechanism to Inhibit Neoplastic Mast Cell Proliferation and Mast Cell Activation
por: Bai, Yun, et al.
Publicado: (2012)

CRISPR/Cas9-engineering of HMC-1.2 cells renders a human mast cell line with a single D816V-KIT mutation: An improved preclinical model for research on mastocytosis
por: Bandara, Geethani, et al.
Publicado: (2023)

ALDH2 deficiency increases susceptibility to binge alcohol-induced gut leakiness, endotoxemia, and acute liver injury in mice through the gut-liver axis
por: Rungratanawanich, Wiramon, et al.
Publicado: (2022)

Mast cell exosomes promote lung adenocarcinoma cell proliferation – role of KIT-stem cell factor signaling
por: Xiao, Hui, et al.
Publicado: (2014)

Mast cell deficiency attenuates acupuncture analgesia for mechanical pain using c-kit gene mutant rats
por: Cui, Xiang, et al.
Publicado: (2018)

Mast Cell Leukaemia: c-KIT Mutations Are Not Always Positive
por: Joris, Magalie, et al.
Publicado: (2012)

The rat c-kit ligand, stem cell factor, induces c-kit receptor- dependent mouse mast cell activation in vivo. Evidence that signaling through the c-kit receptor can induce expression of cellular function
Publicado: (1992)

The c-kit Ligand, Stem Cell Factor, Can Enhance Innate Immunity Through Effects on Mast Cells
por: Maurer, Marcus, et al.
Publicado: (1998)

A Critical Function for the Transcription Factors GLI1 and GLI2 in the Proliferation and Survival of Human Mast Cells
por: Falduto, Guido Hernan, et al.
Publicado: (2022)

Mast cells rescue implantation defects caused by c-kit deficiency
por: Woidacki, K, et al.
Publicado: (2013)

De novo Leukemic Variant of Mast Cell Leukemia With KIT D816V
por: Bang, Hae In, et al.
Publicado: (2015)

The rarity of ALDH (+) cells is the key to separation of normal versus leukemia stem cells by ALDH activity in AML patients
por: Hoang, Van T., et al.
Publicado: (2015)

S1P(4) Regulates Passive Systemic Anaphylaxis in Mice but Is Dispensable for Canonical IgE-Mediated Responses in Mast Cells
por: Kulinski, Joseph M., et al.
Publicado: (2018)

Evaluation of the kinase domain of c-KIT in canine cutaneous mast cell tumors
por: Webster, Joshua D, et al.
Publicado: (2006)

Mutations in C-KIT exon 11 in canine cutaneous mast cell tumors
por: Neto, Rafael T, et al.
Publicado: (2013)

Comparative aspects of mast cell neoplasia in animals and the role of KIT in prognosis and treatment
por: Tamlin, Vanessa S., et al.
Publicado: (2019)

Recombinant human stem cell factor (kit ligand) promotes human mast cell and melanocyte hyperplasia and functional activation in vivo
Publicado: (1996)

KIT D816V Mast Cells Derived from Induced Pluripotent Stem Cells Recapitulate Systemic Mastocytosis Transcriptional Profile
por: de Toledo, Marcelo A. S., et al.
Publicado: (2023)

Oncogenic Kit signals on endolysosomes and endoplasmic reticulum are essential for neoplastic mast cell proliferation
por: Obata, Yuuki, et al.
Publicado: (2014)

Highly Aggressive de novo Aleukemic Variant of Mast Cell Leukemia Without KIT D816V Mutation
por: Suh, Myung Chul, et al.
Publicado: (2017)

MAST4 controls cell cycle in spermatogonial stem cells
por: Lee, Seung‐Jun, et al.
Publicado: (2023)

Transcriptome and proteome analysis of tyrosine kinase inhibitor treated canine mast cell tumour cells identifies potentially kit signaling-dependent genes
por: Klopfleisch, Robert, et al.
Publicado: (2012)

Galiellalactone Inhibits Stem Cell-Like ALDH-Positive Prostate Cancer Cells
por: Hellsten, Rebecka, et al.
Publicado: (2011)

c-kit ligand: a unique potentiator of mediator release by human lung mast cells
Publicado: (1992)

Mast cell deficiency in Kit(W-sh) mice does not impair antibody-mediated arthritis
por: Zhou, Joseph S., et al.
Publicado: (2007)

Cigarette Smoke Suppresses the Surface Expression of c-kit and FcεRI on Mast Cells
por: Givi, M. E., et al.
Publicado: (2013)

Arthritis augments breast cancer metastasis: role of mast cells and SCF/c-Kit signaling
por: Roy, Lopamudra Das, et al.
Publicado: (2013)

C-Kit receptor and tryptase expressing mast cells correlate with angiogenesis in breast cancer patients
por: Marech, Ilaria, et al.
Publicado: (2017)

The pathogenic role of c-Kit+ mast cells in the spinal motor neuron-vascular niche in ALS
por: Kovacs, Mariángeles, et al.
Publicado: (2021)

Detection of ALDH1 activity in rabbit hepatic VX2 tumors and isolation of ALDH1 positive cancer stem cells
por: Gehlot, Prashasnika, et al.
Publicado: (2016)

Mast Cell Dependent Vascular Changes Associated with an Acute Response to Cold Immersion in Primary Contact Urticaria
por: Meyer, Joseph, et al.
Publicado: (2013)

C-Kit Expression, Angiogenesis, and Grading in Canine Mast Cell Tumour: A Unique Model to Study C-Kit Driven Human Malignancies
por: Patruno, Rosa, et al.
Publicado: (2014)

Protein Kinase C α and β compensate for each other to promote stem cell factor‐mediated KIT phosphorylation, mast cell viability and proliferation
por: Teegala, Lakshminarayan Reddy, et al.
Publicado: (2022)

Evidence for a novel Kit adhesion domain mediating human mast cell adhesion to structural airway cells
por: Gough, Kevin C., et al.
Publicado: (2015)

Description and Characterization of a Novel Human Mast Cell Line for Scientific Study
por: S. Kirshenbaum, Arnold, et al.
Publicado: (2019)

Extracellular Vesicles Derived from Human Umbilical Cord Mesenchymal Stem Cells Attenuate Mast Cell Activation
por: Lin, Tzou-Yien, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_vm8lpjd2k2kh9fd5o736r9329p