The Putatively Specific Synthetic REV-ERB Agonist SR9009 Inhibits IgE- and IL-33-Mediated Mast Cell Activation Independently of the Circadian Clock

The cell-autonomous circadian clock regulates IgE- and IL-33-mediated mast cell activation, both of which are key events in the development of allergic diseases. Accordingly, clock modifiers could be used to treat allergic diseases, as well as many other circadian-related diseases, such as sleep and...

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Detalles Bibliográficos
Autores principales: Ishimaru, Kayoko, Nakajima, Shotaro, Yu, Guannan, Nakamura, Yuki, Nakao, Atsuhito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941044/
https://www.ncbi.nlm.nih.gov/pubmed/31847374
http://dx.doi.org/10.3390/ijms20246320

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941044/
https://www.ncbi.nlm.nih.gov/pubmed/31847374
http://dx.doi.org/10.3390/ijms20246320

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