Reductive Activity and Mechanism of Hypoxia- Targeted AGT Inhibitors: An Experimental and Theoretical Investigation

O(6)-alkylguanine-DNA alkyltransferase (AGT) is the main cause of tumor cell resistance to DNA-alkylating agents, so it is valuable to design tumor-targeted AGT inhibitors with hypoxia activation. Based on the existing benchmark inhibitor O(6)-benzylguanine (O(6)-BG), four derivatives with hypoxia-r...

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Detalles Bibliográficos
Autores principales: Xiao, Weinan, Sun, Guohui, Fan, Tengjiao, Liu, Junjun, Zhang, Na, Zhao, Lijiao, Zhong, Rugang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941096/
https://www.ncbi.nlm.nih.gov/pubmed/31847200
http://dx.doi.org/10.3390/ijms20246308

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941096/
https://www.ncbi.nlm.nih.gov/pubmed/31847200
http://dx.doi.org/10.3390/ijms20246308

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