Mutation of Aspartate 238 in FAD Synthase Isoform 6 Increases the Specific Activity by Weakening the FAD Binding

FAD synthase (FADS, or FMN:ATP adenylyl transferase) coded by the FLAD1 gene is the last enzyme in the pathway of FAD synthesis. The mitochondrial isoform 1 and the cytosolic isoform 2 are characterized by the following two domains: the C-terminal PAPS domain (FADSy) performing FAD synthesis and pyr...

Descripción completa

Detalles Bibliográficos
Autores principales: Leone, Piero, Galluccio, Michele, Quarta, Stefano, Anoz-Carbonell, Ernesto, Medina, Milagros, Indiveri, Cesare, Barile, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941110/
https://www.ncbi.nlm.nih.gov/pubmed/31835305
http://dx.doi.org/10.3390/ijms20246203

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941110/
https://www.ncbi.nlm.nih.gov/pubmed/31835305
http://dx.doi.org/10.3390/ijms20246203

Ejemplares similares