Lercanidipine Synergistically Enhances Bortezomib Cytotoxicity in Cancer Cells via Enhanced Endoplasmic Reticulum Stress and Mitochondrial Ca(2+) Overload

The proteasome inhibitor (PI), bortezomib (Btz), is effective in treating multiple myeloma and mantle cell lymphoma, but not solid tumors. In this study, we show for the first time that lercanidipine (Ler), an antihypertensive drug, enhances the cytotoxicity of various PIs, including Btz, carfilzomi...

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Detalles Bibliográficos
Autores principales: Lee, A Reum, Seo, Min Ji, Kim, Jin, Lee, Dong Min, Kim, In Young, Yoon, Mi Jin, Hoon, Hur, Choi, Kyeong Sook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941136/
https://www.ncbi.nlm.nih.gov/pubmed/31817163
http://dx.doi.org/10.3390/ijms20246112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941136/
https://www.ncbi.nlm.nih.gov/pubmed/31817163
http://dx.doi.org/10.3390/ijms20246112

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