Antiviral Immune Response as a Trigger of FUS Proteinopathy in Amyotrophic Lateral Sclerosis

Mutations in the FUS gene cause familial amyotrophic lateral sclerosis (ALS-FUS). In ALS-FUS, FUS-positive inclusions are detected in the cytoplasm of neurons and glia, a condition known as FUS proteinopathy. Mutant FUS incorporates into stress granules (SGs) and can spontaneously form cytoplasmic R...

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Detalles Bibliográficos
Autores principales: Shelkovnikova, Tatyana A., An, Haiyan, Skelt, Lucy, Tregoning, John S., Humphreys, Ian R., Buchman, Vladimir L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941233/
https://www.ncbi.nlm.nih.gov/pubmed/31875556
http://dx.doi.org/10.1016/j.celrep.2019.11.094

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941233/
https://www.ncbi.nlm.nih.gov/pubmed/31875556
http://dx.doi.org/10.1016/j.celrep.2019.11.094

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