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The SMAC mimetic LCL-161 selectively targets JAK2(V617F) mutant cells
BACKGROUND: Evasion from programmed cell death is a hallmark of cancer and can be achieved in cancer cells by overexpression of inhibitor of apoptosis proteins (IAPs). Second mitochondria-derived activator of caspases (SMAC) directly bind to IAPs and promote apoptosis; thus, SMAC mimetics have been...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941266/ https://www.ncbi.nlm.nih.gov/pubmed/31908904 http://dx.doi.org/10.1186/s40164-019-0157-6 |