Tissue of origin dictates GOT1 dependence and confers synthetic lethality to radiotherapy

BACKGROUND: Metabolic programs in cancer cells are influenced by genotype and the tissue of origin. We have previously shown that central carbon metabolism is rewired in pancreatic ductal adenocarcinoma (PDA) to support proliferation through a glutamate oxaloacetate transaminase 1 (GOT1)-dependent p...

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Detalles Bibliográficos
Autores principales: Nelson, Barbara S., Lin, Lin, Kremer, Daniel M., Sousa, Cristovão M., Cotta-Ramusino, Cecilia, Myers, Amy, Ramos, Johanna, Gao, Tina, Kovalenko, Ilya, Wilder-Romans, Kari, Dresser, Joseph, Davis, Mary, Lee, Ho-Joon, Nwosu, Zeribe C., Campit, Scott, Mashadova, Oksana, Nicolay, Brandon N., Tolstyka, Zachary P., Halbrook, Christopher J., Chandrasekaran, Sriram, Asara, John M., Crawford, Howard C., Cantley, Lewis C., Kimmelman, Alec C., Wahl, Daniel R., Lyssiotis, Costas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941320/
https://www.ncbi.nlm.nih.gov/pubmed/31908776
http://dx.doi.org/10.1186/s40170-019-0202-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941320/
https://www.ncbi.nlm.nih.gov/pubmed/31908776
http://dx.doi.org/10.1186/s40170-019-0202-2

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