Cargando…

Dysregulation of RNA Splicing in Tauopathies

Pathological aggregation of RNA binding proteins (RBPs) is associated with dysregulation of RNA splicing in PS19 P301S tau transgenic mice and in Alzheimer’s disease brain tissues. The dysregulated splicing particularly affects genes involved in synaptic transmission. The effects of neuroprotective...

Descripción completa

Detalles Bibliográficos
Autores principales:	Apicco, Daniel J., Zhang, Cheng, Maziuk, Brandon, Jiang, Lulu, Ballance, Heather I., Boudeau, Samantha, Ung, Choong, Li, Hu, Wolozin, Benjamin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941411/ https://www.ncbi.nlm.nih.gov/pubmed/31875547 http://dx.doi.org/10.1016/j.celrep.2019.11.093

Ejemplares similares

Dysregulation of RNA Binding Protein Aggregation in Neurodegenerative Disorders
por: Maziuk, Brandon, et al.
Publicado: (2017)

RNA binding proteins co-localize with small tau inclusions in tauopathy
por: Maziuk, Brandon F., et al.
Publicado: (2018)

TIA1 regulates the generation and response to toxic tau oligomers
por: Jiang, Lulu, et al.
Publicado: (2018)

Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo
por: Apicco, Daniel J., et al.
Publicado: (2017)

Single cell transcriptomic profiling of a neuron-astrocyte assembloid tauopathy model
por: Rickner, Hannah Drew, et al.
Publicado: (2022)

Tau exon 10 alternative splicing and tauopathies
por: Liu, Fei, et al.
Publicado: (2008)

Reduction of the RNA Binding Protein TIA1 Exacerbates Neuroinflammation in Tauopathy
por: LeBlang, Chelsey Jenna, et al.
Publicado: (2020)

Dioxins and related environmental contaminants increase TDP-43 levels
por: Ash, Peter E. A., et al.
Publicado: (2017)

Tau Oligomers and Fibrils Exhibit Differential Patterns of Seeding and Association With RNA Binding Proteins
por: Jiang, Lulu, et al.
Publicado: (2020)

THE ROLE OF CAPRIN-1 PROTEIN DYSREGULATION IN SYNAPSE DECLINE LEADING TO PROGRESSION OF TAUOPATHIES
por: Fastenau, Caitlyn, et al.
Publicado: (2019)

Alternative splicing of exon 10 in the tau gene as a target for treatment of tauopathies
por: Zhou, Jianhua, et al.
Publicado: (2008)

Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies
por: Sun, Wenyan, et al.
Publicado: (2018)

Heritability in frontotemporal tauopathies
por: Forrest, Shelley L., et al.
Publicado: (2019)

MAPT expression and splicing is differentially regulated by brain region: relation to genotype and implication for tauopathies
por: Trabzuni, Daniah, et al.
Publicado: (2012)

Delta-secretase (AEP) mediates tau-splicing imbalance and accelerates cognitive decline in tauopathies
por: Wang, Zhi-Hao, et al.
Publicado: (2018)

Astrocytes in Tauopathies
por: Reid, Matthew J., et al.
Publicado: (2020)

Dysregulated minor intron splicing in cancer
por: Nishimura, Koutarou, et al.
Publicado: (2022)

TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy
por: Bemiller, Shane M., et al.
Publicado: (2017)

Clinical Spectrum of Tauopathies
por: Olfati, Nahid, et al.
Publicado: (2022)

Mutations in DARS2 result in global dysregulation of mRNA metabolism and splicing
por: Guang, Shiqi, et al.
Publicado: (2023)

Mutations in DARS2 result in global dysregulation of mRNA metabolism and splicing
por: Guang, S., et al.
Publicado: (2023)

Widespread dysregulation of mRNA splicing implicates RNA processing in the development and progression of Huntington's disease
por: Tano, Vincent, et al.
Publicado: (2023)

Splicing dysregulation as a driver of breast cancer
por: Read, Abigail, et al.
Publicado: (2018)

Biology of the mRNA Splicing Machinery and Its Dysregulation in Cancer Providing Therapeutic Opportunities
por: Blijlevens, Maxime, et al.
Publicado: (2021)

Genome-wide analysis of dysregulated RNA-binding proteins and alternative splicing genes in keloid
por: Zhu, Zhen, et al.
Publicado: (2023)

Basal ganglia echogenicity in tauopathies
por: Sadowski, Krzysztof, et al.
Publicado: (2014)

Transcellular Spreading of Tau in Tauopathies
por: Demaegd, Koen, et al.
Publicado: (2018)

Glial contributions to neurodegeneration in tauopathies
por: Leyns, Cheryl E. G., et al.
Publicado: (2017)

Glial tauopathy: Neurons optional?
por: Walker, Lary C.
Publicado: (2019)

Pneumonia initiates a tauopathy
por: Balczon, Ron, et al.
Publicado: (2021)

Tauopathies: new perspectives and challenges
por: Zhang, Yi, et al.
Publicado: (2022)

Corrigendum: Clinical spectrum of tauopathies
por: Olfati, Nahid, et al.
Publicado: (2022)

Heparan Sulfate Proteoglycans in Tauopathy
por: Zhu, Yanan, et al.
Publicado: (2022)

TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau
por: Ash, Peter E. A., et al.
Publicado: (2021)

A functional network of gastric-cancer-associated splicing events controlled by dysregulated splicing factors
por: Cheng, Shanshan, et al.
Publicado: (2020)

Involvement of Oligodendrocytes in Tau Seeding and Spreading in Tauopathies
por: Ferrer, Isidro, et al.
Publicado: (2019)

Dysregulation of alternative splicing is associated with the pathogenesis of ulcerative colitis
por: Li, Daowei, et al.
Publicado: (2021)

A widespread length-dependent splicing dysregulation in cancer
por: Zhang, Sirui, et al.
Publicado: (2022)

Immunomodulatory Gene-Splicing Dysregulation in Tumorigenesis: Unmasking the Complexity
por: Maebele, Lorraine Tshegofatso, et al.
Publicado: (2023)

LRRK2 phosphorylates novel tau epitopes and promotes tauopathy
por: Bailey, Rachel M., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_vroii4couhegd2529vigl6e3tb