The role of mutations at codons 32, 47, 54, and 90 in HIV-1 protease flap dynamics

Treatment of Human Immunodeficiency Virus remains challenging due to the emergence of drug resistant strains under the selective pressure produced by standard anti-retroviral therapy. To explore the structural mechanisms of drug resistance, we performed 40 ns molecular dynamics simulations on three...

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Detalles Bibliográficos
Autores principales: Chordia, Poorvi, Dewdney, Tamaria G., Keusch, Bradley, Kuiper, Benjamin D., Ross, Kyla, Kovari, Iulia A., MacArthur, Rodger, Salimnia, Hossein, Kovari, Ladislau C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Applied Systems srl 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941557/
https://www.ncbi.nlm.nih.gov/pubmed/32309558
http://dx.doi.org/10.15190/d.2014.19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941557/
https://www.ncbi.nlm.nih.gov/pubmed/32309558
http://dx.doi.org/10.15190/d.2014.19

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