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LIR motifs and the membrane-targeting domain are complementary in the function of RavZ

The bacterial effector protein RavZ is secreted by the intracellular pathogen Legionella pneumophila and inhibits host autophagy through an irreversible deconjugation of mammalian ATG8 (mATG8) proteins from autophagosome membranes. However, the roles of the LC3 interacting region (LIR) motifs in Rav...

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Detalles Bibliográficos
Autores principales: Park, Sang-Won, Jun, Yong-Woo, Jeon, Pureum, Lee, You-Kyung, Park, Ju-Hui, Lee, Seung-Hwan, Lee, Jin-A, Jang, Deok-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941762/
https://www.ncbi.nlm.nih.gov/pubmed/31722778
http://dx.doi.org/10.5483/BMBRep.2019.52.12.211