In vivo elongation of thin filaments results in heart failure

A novel cardiac-specific transgenic mouse model was generated to identify the physiological consequences of elongated thin filaments during post-natal development in the heart. Remarkably, increasing the expression levels in vivo of just one sarcomeric protein, Lmod2, results in ~10% longer thin fil...

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Detalles Bibliográficos
Autores principales: Mi-Mi, Lei, Farman, Gerrie P., Mayfield, Rachel M., Strom, Joshua, Chu, Miensheng, Pappas, Christopher T., Gregorio, Carol C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941805/
https://www.ncbi.nlm.nih.gov/pubmed/31899774
http://dx.doi.org/10.1371/journal.pone.0226138

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941805/
https://www.ncbi.nlm.nih.gov/pubmed/31899774
http://dx.doi.org/10.1371/journal.pone.0226138

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