Mutations that improve efficiency of a weak-link enzyme are rare compared to adaptive mutations elsewhere in the genome

New enzymes often evolve by gene amplification and divergence. Previous experimental studies have followed the evolutionary trajectory of an amplified gene, but have not considered mutations elsewhere in the genome when fitness is limited by an evolving gene. We have evolved a strain of Escherichia...

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Detalles Bibliográficos
Autores principales: Morgenthaler, Andrew B, Kinney, Wallis R, Ebmeier, Christopher C, Walsh, Corinne M, Snyder, Daniel J, Cooper, Vaughn S, Old, William M, Copley, Shelley D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Evolutionary Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941894/
https://www.ncbi.nlm.nih.gov/pubmed/31815667
http://dx.doi.org/10.7554/eLife.53535

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941894/
https://www.ncbi.nlm.nih.gov/pubmed/31815667
http://dx.doi.org/10.7554/eLife.53535

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