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Mutations that improve efficiency of a weak-link enzyme are rare compared to adaptive mutations elsewhere in the genome
New enzymes often evolve by gene amplification and divergence. Previous experimental studies have followed the evolutionary trajectory of an amplified gene, but have not considered mutations elsewhere in the genome when fitness is limited by an evolving gene. We have evolved a strain of Escherichia...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941894/ https://www.ncbi.nlm.nih.gov/pubmed/31815667 http://dx.doi.org/10.7554/eLife.53535 |