ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway

The accumulation of damaged mitochondria causes the death of dopaminergic neurons. The Parkin-mediated mitophagy pathway functions to remove these mitochondria from cells. Targeting this pathway represents a therapeutic strategy for several neurodegenerative diseases, most notably Parkinson’s diseas...

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Detalles Bibliográficos
Autores principales: Moskal, Natalia, Riccio, Victoria, Bashkurov, Mikhail, Taddese, Rediet, Datti, Alessandro, Lewis, Peter N., Angus McQuibban, G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941965/
https://www.ncbi.nlm.nih.gov/pubmed/31900402
http://dx.doi.org/10.1038/s41467-019-13781-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941965/
https://www.ncbi.nlm.nih.gov/pubmed/31900402
http://dx.doi.org/10.1038/s41467-019-13781-3

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