NHC-gold compounds mediate immune suppression through induction of AHR-TGFβ1 signalling in vitro and in scurfy mice

Gold compounds have a long history of use as immunosuppressants, but their precise mechanism of action is not completely understood. Using our recently developed liver-on-a-chip platform we now show that gold compounds containing planar N-heterocyclic carbene (NHC) ligands are potent ligands for the...

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Detalles Bibliográficos
Autores principales: Cheng, Xinlai, Haeberle, Stefanie, Shytaj, Iart Luca, Gama-Brambila, Rodrigo. A., Theobald, Jannick, Ghafoory, Shahrouz, Wölker, Jessica, Basu, Uttara, Schmidt, Claudia, Timm, Annika, Taškova, Katerina, Bauer, Andrea S., Hoheisel, Jörg, Tsopoulidis, Nikolaos, Fackler, Oliver T., Savarino, Andrea, Andrade-Navarro, Miguel A., Ott, Ingo, Lusic, Marina, Hadaschik, Eva N., Wölfl, Stefan.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941985/
https://www.ncbi.nlm.nih.gov/pubmed/31909202
http://dx.doi.org/10.1038/s42003-019-0716-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941985/
https://www.ncbi.nlm.nih.gov/pubmed/31909202
http://dx.doi.org/10.1038/s42003-019-0716-8

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