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Gastric squamous-columnar junction contains a large pool of cancer-prone immature osteopontin responsive Lgr5(−)CD44(+) cells
Areas of a junction between two types of epithelia are known to be cancer-prone in many organ systems. However, mechanisms for preferential malignant transformation at the junction areas remain insufficiently elucidated. Here we report that inactivation of tumor suppressor genes Trp53 and Rb1 in the...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941991/ https://www.ncbi.nlm.nih.gov/pubmed/31901081 http://dx.doi.org/10.1038/s41467-019-13847-2 |