Is population structure in the genetic biobank era irrelevant, a challenge, or an opportunity?

Replicable genetic association signals have consistently been found through genome-wide association studies in recent years. The recent dramatic expansion of study sizes improves power of estimation of effect sizes, genomic prediction, causal inference, and polygenic selection, but it simultaneously...

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Detalles Bibliográficos
Autores principales: Lawson, Daniel John, Davies, Neil Martin, Haworth, Simon, Ashraf, Bilal, Howe, Laurence, Crawford, Andrew, Hemani, Gibran, Davey Smith, George, Timpson, Nicholas John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942007/
https://www.ncbi.nlm.nih.gov/pubmed/31030318
http://dx.doi.org/10.1007/s00439-019-02014-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942007/
https://www.ncbi.nlm.nih.gov/pubmed/31030318
http://dx.doi.org/10.1007/s00439-019-02014-8

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