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Is population structure in the genetic biobank era irrelevant, a challenge, or an opportunity?
Replicable genetic association signals have consistently been found through genome-wide association studies in recent years. The recent dramatic expansion of study sizes improves power of estimation of effect sizes, genomic prediction, causal inference, and polygenic selection, but it simultaneously...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942007/ https://www.ncbi.nlm.nih.gov/pubmed/31030318 http://dx.doi.org/10.1007/s00439-019-02014-8 |