Model-Based Characterization of the Pharmacokinetics, Target Engagement Biomarkers, and Immunomodulatory Activity of PF-06342674, a Humanized mAb Against IL-7 Receptor-α, in Adults with Type 1 Diabetes

IL-7 receptor-α (IL-7Rα) blockade has been shown to reverse autoimmune diabetes in the non-obese diabetic mouse by promoting inhibition of effector T cells and consequently altering the balance of regulatory T (T(reg)) and effector memory (T(EM)) cells. PF-06342674 is a humanized monoclonal antibody...

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Detalles Bibliográficos
Autores principales: Williams, Jason H., Udata, Chandrasekhar, Ganguly, Bishu J., Bucktrout, Samantha L., Joh, Tenshang, Shannon, Megan, Wong, Gilbert Y., Levisetti, Matteo, Garzone, Pamela D., Meng, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942017/
https://www.ncbi.nlm.nih.gov/pubmed/31900603
http://dx.doi.org/10.1208/s12248-019-0401-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942017/
https://www.ncbi.nlm.nih.gov/pubmed/31900603
http://dx.doi.org/10.1208/s12248-019-0401-3

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